Article
Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits.
PloS one - 1 Jan 2012
McKnite Autumn M, Perez-Munoz Maria Elisa, Lu Lu, Williams Evan G, Brewer Simon, Andreux Pénélope A, Bastiaansen John W M, Wang Xusheng, Kachman Stephen D, Auwerx Johan, Williams Robert W, Benson Andrew K, Peterson Daniel A, Ciobanu Daniel C
Abstract excerpt
The gastrointestinal tract harbors a complex and diverse microbiota that has an important role in host metabolism. Microbial diversity is influenced by a combination of environmental and host genetic factors and is associated with several polygenic diseases. In this study we combined next-generation sequencing, genetic mapping, and a set of physiological traits of the BXD mouse population to explore genetic...
Topics
- Animals
- Bacteroidaceae
- Chromosome Mapping
- Chromosomes, Mammalian
- Gene-Environment Interaction
- Genetic Variation
- Genome-Wide Association Study
- Host-Pathogen Interactions
- Intestines
- Metagenome
- Mice
- Quantitative Trait Loci