Article
Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population.
eLife - 19 Oct 2023
Li Xiaoxu, Morel Jean-David, Benegiamo Giorgia, Poisson Johanne, Bachmann Alexis, Rapin Alexis, Sulc Jonathan, Williams Evan, Perino Alessia, Schoonjans Kristina, Bou Sleiman Maroun, Auwerx Johan
Abstract excerpt
Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment interactions underlying inflammation and IBD. Here, we profiled the colon transcriptome of 52 BXD mouse strains fed with a chow or high-fat diet (HFD) and...
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