Article
Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut.
Nature microbiology - 1 Mar 2023
Zhang Qijun, Linke Vanessa, Overmyer Katherine A, Traeger Lindsay L, Kasahara Kazuyuki, Miller Ian J, Manson Daniel E, Polaske Thomas J, Kerby Robert L, Kemis Julia H, Trujillo Edna A, Reddy Thiru R, Russell Jason D, Schueler Kathryn L, Stapleton Donald S, Rabaglia Mary E, Seldin Marcus, Gatti Daniel M, Keele Gregory R, Pham Duy T, Gerdt Joseph P, Vivas Eugenio I, Lusis Aldons J, Keller Mark P, Churchill Gary A, Blackwell Helen E, Broman Karl W, Attie Alan D, Coon Joshua J, Rey Federico E
Abstract excerpt
The molecular bases of how host genetic variation impacts the gut microbiome remain largely unknown. Here we used a genetically diverse mouse population and applied systems genetics strategies to identify interactions between host and microbe phenotypes including microbial functions, using faecal metagenomics, small intestinal transcripts and caecal lipids that influence microbe-host dynamics. Quantitative trait...
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