Article
Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors.
Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2010
Benson Andrew K, Kelly Scott A, Legge Ryan, Ma Fangrui, Low Soo Jen, Kim Jaehyoung, Zhang Min, Oh Phaik Lyn, Nehrenberg Derrick, Hua Kunjie, Kachman Stephen D, Moriyama Etsuko N, Walter Jens, Peterson Daniel A, Pomp Daniel
Abstract excerpt
In vertebrates, including humans, individuals harbor gut microbial communities whose species composition and relative proportions of dominant microbial groups are tremendously varied. Although external and stochastic factors clearly contribute to the individuality of the microbiota, the fundamental principles dictating how environmental factors and host genetic factors combine to shape this complex ecosystem are...
Topics
- Animals
- Bacteria
- Breeding
- Genetic Linkage
- Genome-Wide Association Study
- Host-Pathogen Interactions
- Humans
- Intestines
- Mice