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Digital detection of multiple minority mutants in stool DNA for noninvasive colorectal cancer diagnosis.

Analytical chemistry - 3 Jul 2012

Deng Lili, Qi Zongtai, Zou Binjie, Wu Haiping, Huang Huan, Kajiyama Tomoharu, Kambara Hideki, Zhou Guohua

Abstract excerpt

Somatic mutations in stool DNA are quite specific to colorectal cancer (CRC), but a method being able to detect the extraordinarily low amounts of mutants is challengeable in sensitivity. We proposed a hydrogel bead-array to digitally count CRC-specific mutants in stool at a low cost. At first, multiplex amplification of targets containing multiple mutation loci of interest is carried out by a target enriched...

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Identifiers

PMID: 22715805
DOI: 10.1021/ac3008016

Genes

APC
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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