Article
Quantitative and sensitive detection of rare mutations using droplet-based microfluidics.
Lab on a chip - 7 Jul 2011
Pekin Deniz, Skhiri Yousr, Baret Jean-Christophe, Le Corre Delphine, Mazutis Linas, Salem Chaouki Ben, Millot Florian, El Harrak Abdeslam, Hutchison J Brian, Larson Jonathan W, Link Darren R, Laurent-Puig Pierre, Griffiths Andrew D, Taly Valérie
Abstract excerpt
Somatic mutations within tumoral DNA can be used as highly specific biomarkers to distinguish cancer cells from their normal counterparts. These DNA biomarkers are potentially useful for the diagnosis, prognosis, treatment and follow-up of patients. In order to have the required sensitivity and specificity to detect rare tumoral DNA in stool, blood, lymph and other patient samples, a simple, sensitive and...
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