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Article

Analytical sensitivity and stability of DNA methylation testing in stool samples for colorectal cancer detection.

Cellular oncology (Dordrecht, Netherlands) - 1 Aug 2012

Bosch Linda J W, Mongera Sandra, Terhaar Sive Droste Jochim S, Oort Frank A, van Turenhout Sietze T, Penning Maarten T, Louwagie Joost, Mulder Chris J J, van Engeland Manon, Carvalho Beatriz, Meijer Gerrit A

Abstract excerpt

BACKGROUND: Stool-based molecular tests hold large potential for improving colorectal cancer screening. Here, we investigated the analytical sensitivity of a DNA methylation assay on partial stool samples, and estimated the DNA degradation in stool over time. In addition, we explored the detection of DNA methylation in fecal immunochemical test (FIT) fluid. MATERIALS AND METHODS: Partial stool samples of...

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Identifiers

PMID: 22821210
DOI: 10.1007/s13402-012-0092-6
PMCID: PMC12994984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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