Article
The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory.
American journal of human genetics - 8 Jan 2026
Dybdahl Krebs M, Appadurai Vivek, Georgii Hellberg Kajsa-Lotta, Ohlsson Henrik, Steinbach Jette, Pedersen Emil, Werge Thomas, Sundquist Jan, Sundquist Kristina, Border Richard, Cai Na, Zaitlen Noah, Dahl Andy, Vilhjalmsson Bjarni, Flint Jonathan, Bacanu Silviu-Alin, Kendler Kenneth S, Schork Andrew J
Abstract excerpt
Genetics as a science has roots in studying phenotypes of relatives, but molecular approaches facilitate direct measurements of genomic variation between individuals. Agricultural and human biomedical research are both emphasizing genotype-based instruments, such as polygenic scores, but unlike in agriculture, there is an emerging consensus that family variables act nearly independently of genotypes in models of...
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