Article
The potential of genes and other markers to inform about risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2010
Pepe Margaret S, Gu Jessie W, Morris Daryl E
Abstract excerpt
BACKGROUND: Advances in biotechnology have raised expectations that biomarkers, including genetic profiles, will yield information to accurately predict outcomes for individuals. However, results to date have been disappointing. In addition, statistical methods to quantify the predictive information in markers have not been standardized. METHODS: We discuss statistical techniques to summarize predictive...
Topics
- Biomarkers
- Genetic Predisposition to Disease
- Genetic Testing
- Humans
- Models, Statistical
- Odds Ratio
- Predictive Value of Tests
- ROC Curve
- Risk
- Risk Assessment