Article
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
The EMBO journal - 15 Jun 2021
Steubler Vicky, Erdinger Susanne, Back Michaela K, Ludewig Susann, Fässler Dominique, Richter Max, Han Kang, Slomianka Lutz, Amrein Irmgard, von Engelhardt Jakob, Wolfer David P, Korte Martin, Müller Ulrike C
Abstract excerpt
The key role of APP for Alzheimer pathogenesis is well established. However, perinatal lethality of germline knockout mice lacking the entire APP family has so far precluded the analysis of its physiological functions for the developing and adult brain. Here, we generated conditional APP/APLP1/APLP2 triple KO (cTKO) mice lacking the APP family in excitatory forebrain neurons from embryonic day 11.5 onwards....
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