Article
Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant Abeta-bearing fragment is associated with reduced NMDA receptor density.
Behavioural brain research - 1 May 2010
Boon Wah Chin, van den Buuse Maarten, Wegener Nico, Martin Sally, Chua Hui Kheng, Bush Ashley I, Masters Colin L, Adlard Paul A, Li Qiao-Xin
Abstract excerpt
The aim of this study was to characterize APPC100.V717F transgenic (TgC100.V717F) mice which over-express a mutant C100 fragment of the amyloid precursor protein. The mice were compared to TgC100 wild type mice (TgC100.WT) and non-transgenic controls at 4-9 and 16-22 months of age. TgC100.V717F mice showed behavioural hyperactivity, particularly at a younger age, as shown by increased numbers of elevated plus...
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