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Aggressive behaviour in transgenic mice expressing APP is alleviated by serotonergic drugs

1 Nov 1998

Abstract excerpt

Transgenic mouse strains were generated that overexpress human APP or clinical mutants of APP. All transgenic mouse strains that over-express APP displayed essentially the same phenotype of disturbed behaviour, differential glutamatergic responses, deficits in maintenance of long-term potentiation and premature death, but formation of amyloid plaques was seen in the highest expressing APP/London transgenic mice...

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PMID: 9858360
DOI: 10.1097/00001756-199811160-00004

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