Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormal exploratory behavior in transgenic mice carrying multiple copies of the human gene for S100 beta.

Journal of psychiatry & neuroscience : JPN - 1 Mar 1995

Gerlai R, Roder J

Abstract excerpt

S100 beta, a calcium-binding brain protein, has been implicated in brain development and hippocampal neurophysiology including long-term potentiation. Its gene maps to chromosome 21, which is duplicated in Down syndrome. S100 beta levels are elevated in both Down syndrome and Alzheimer's disease, human neurodegenerative diseases associated with mental retardation and dementia. To investigate whether or not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arousal
Share to Genotype
Share to Hippocampus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Maze Learning

Share to Mice, Transgenic

Share to Motor Activity

Share to S100 Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7703219
PMCID: PMC1188669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal exploratory behavior in transgenic mice carrying multiple copies of the human gene for S100 beta.PMID 7703219Read ↗

Female specific hyperactivity in S100 beta transgenic mice does not habituate in open-field.Semantic proximity Read ↗

T-maze spontaneous alternation rate is decreased in S100 beta transgenic mice.Semantic proximity Read ↗

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.Semantic proximity Read ↗

Transgenic mice overexpressing the neurotrophic factor S-100β show neuronal cytoskeletal and behavioral signs of altered aging processes: implications for Alzheimer's disease and Down's syndromeSemantic proximity Read ↗

Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination.Semantic proximity Read ↗

Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordination.Semantic proximity Read ↗

Learning and Memory in S100-β Transgenic Mice: An Analysis of Impaired and Preserved FunctionSemantic proximity Read ↗

S100A1-deficient male mice exhibit increased exploratory activity and reduced anxiety-related responses.Semantic proximity Read ↗

Brain phenotype of transgenic mice overexpressing cystathionine β-synthase.Semantic proximity Read ↗

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes.Semantic proximity Read ↗

Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease.Semantic proximity Read ↗

Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in male mice with Down SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.