Abnormal exploratory behavior in transgenic mice carrying multiple copies of the human gene for S100 beta.

Article

Abnormal exploratory behavior in transgenic mice carrying multiple copies of the human gene for S100 beta.

Journal of psychiatry & neuroscience : JPN - 1 Mar 1995

Gerlai R, Roder J

Abstract excerpt

S100 beta, a calcium-binding brain protein, has been implicated in brain development and hippocampal neurophysiology including long-term potentiation. Its gene maps to chromosome 21, which is duplicated in Down syndrome. S100 beta levels are elevated in both Down syndrome and Alzheimer's disease,...

Topics

Animals
Arousal
Exploratory Behavior
Female
Genotype
Habituation, Psychophysiologic
Hippocampus
Long-Term Potentiation
Male
Maze Learning
Mental Recall
Mice
Mice, Transgenic
Motor Activity
S100 Proteins

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