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Article

USP7 mediates TRAF4 deubiquitination to facilitate the malignant phenotype of ovarian cancer via the RSK4/PI3K/AKT axis.

Journal of cancer research and therapeutics - 1 Feb 2023

Wang Ying, Luo Xia, Wu Nayiyuan, Liao Qianjin, Wang Jing

Abstract excerpt

Background: Ubiquitin-specific peptidase 7 (USP7) is upregulated in multiple human cancers, including ovarian cancer; however, its functional role in the latter remains largely unknown. Methods: We conducted quantitative real-time PCR to detect the expression of USP7, TRAF4, and RSK4 in ovarian cancer cell lines. In addition, Western blotting served to determine USP7, TRAF4, RSK4, PI3K, and AKT (protein kinase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37006049
DOI: 10.4103/jcrt.jcrt_517_22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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