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Article

TGF-β upregulates the translation of USP15 via the PI3K/AKT pathway to promote p53 stability

28 Nov 2016

Abstract excerpt

Crosstalk between transforming growth factor beta (TGF-β) signaling and p53 has a critical role in cancer progression. TGF-β signals via Smad and non-Smad pathways. Under normal conditions, wild-type p53 forms a complex with Smad2/3 and co-activates transcription of a variety of tumor suppressor genes, resulting in tumor suppressive effects. Thus, p53 stability is essential in progression of tumor suppressive...

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PMID: 27893708
DOI: 10.1038/onc.2016.424

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