Effect of the Arg389Gly β₁-adrenoceptor polymorphism on plasma renin activity and heart rate, and the genotype-dependent response to metoprolol treatment.

doi:10.1111/j.1440-1681.2012.05736.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Effect of the Arg389Gly β₁-adrenoceptor polymorphism on plasma renin activity and heart rate, and the genotype-dependent response to metoprolol treatment.

Clinical and experimental pharmacology & physiology - 1 Sept 2012

Petersen Morten, Andersen Jon T, Jimenez-Solem Espen, Broedbaek Kasper, Hjelvang Brian R, Henriksen Trine, Frandsen Erik, Forman Julie L, Torp-Pedersen Christian, Køber Lars, Poulsen Henrik E

Abstract excerpt

1. A gene-drug interaction has been indicated between β₁-adrenoceptor-selective beta-blockers and the Arg389Gly polymorphism (rs1801253) in the adrenergic beta-1 receptor gene (ADRB1). In the present study, we investigated the effect of the ADRB1 Arg389Gly polymorphism on plasma renin activity (PRA) and heart rate (HR), as well as genotype-dependent responses to metoprolol and exercise. 2. Twenty-nine healthy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Over Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Denmark

Share to Exercise Test

Share to Heart Rate

Share to Metoprolol

Share to Receptors, Adrenergic, beta-1

Share to Renin

Share to Renin-Angiotensin System

Source

Open in PubMed

Identifiers

PMID: 22703382
DOI: 10.1111/j.1440-1681.2012.05736.x

Genes

ADRB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of the Arg389Gly β₁-adrenoceptor polymorphism on plasma renin activity and heart rate, and the genotype-dependent response to metoprolol treatment.PMID 22703382Read ↗

Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol.Semantic proximity Read ↗

The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity.Semantic proximity Read ↗

A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade.Semantic proximity Read ↗

Effects of polymorphisms in beta1-adrenoceptor and alpha-subunit of G protein on heart rate and blood pressure during exercise test. The Finnish Cardiovascular Study.Semantic proximity Read ↗

Effects of sex and the common ADRB1 389 genetic polymorphism on the hemodynamic response to dobutamine.Semantic proximity Read ↗

Functional effects of β₁-adrenoceptor polymorphisms on the hemodynamic response to dobutamine with and without β-blocker administration.Semantic proximity Read ↗

Genetic polymorphisms of beta1 adrenergic receptor and their influence on the cardiovascular responses to metoprolol in a South Indian population.Semantic proximity Read ↗

The Arg389Gly ??1-adrenoceptor gene polymorphism determines contractile response to catecholaminesSemantic proximity Read ↗

Beta-2-adrenergic receptor polymorphisms and changes in lipids induced by metoprolol.Semantic proximity Read ↗

Impact of the β1-adrenoceptor Arg389Gly polymorphism on heart-rate responses to bisoprolol and carvedilol in heart-failure patients.Semantic proximity Read ↗

Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol.Semantic proximity Read ↗

[Polymorphisms of Arg389Gly of β1-adrenergic receptor gene and essential hypertension risk: a meta analysis].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.