Article
Beta-2-adrenergic receptor polymorphisms and changes in lipids induced by metoprolol.
Pharmacology - 1 Jan 2007
Isaza Carlos A, Henao Julieta, Sánchez Julio C, Porras Gloria L, Cardona J, Bedoya G
Abstract excerpt
Polymorphisms Arg(16)Gly and Gln(27)Glu of the gene of adrenoreceptor beta(2)(ADRB2) are associated with altered sympathetic responses. This study evaluated the relationship between these polymorphisms and changes in lipids induced by metoprolol in hypertensive patients. 105 adults were enrolled. After serum lipid levels and genotype had been determined, metoprolol was administered orally. Genotyping was...
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