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Article

Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasis.

The Journal of infectious diseases - 15 Aug 2012

Ouf Eman Abou, Ojurongbe Olusola, Akindele Akeem A, Sina-Agbaje Olawumi R, Van Tong Hoang, Adeyeba Adegboyega O, Kremsner Peter G, Kun Jürgen F J, Velavan Tp

Abstract excerpt

BACKGROUND: Human ficolin-2 (L-ficolins) encoded by the FCN2 gene are pattern-recognition proteins involved in innate immunity and are associated with several infectious diseases. METHODS: A Nigerian cohort of 168 Schistosoma haematobium-infected individuals and 192 healthy controls were examined for functional single-nucleotide polymorphisms in the promoter region (-986G>A, -602G>A, -4A>G) and in exon 8...

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Source

Identifiers

PMID: 22693230
DOI: 10.1093/infdis/jis396

Genes

FCN2

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