Prefrontal deviations in function but not volume are putative endophenotypes for schizophrenia.

Abstract excerpt

This study sought to systematically investigate whether prefrontal cortex grey matter volume reductions are valid endophenotypes for schizophrenia, specifically investigating their presence in unaffected relatives, heritability, genetic overlap with the disorder itself and finally to contrast their performance on these criteria with putative neuropsychological indices of prefrontal functioning. We used a combined...

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• Atrophy
• Brain Mapping
• Endophenotypes
• Executive Function
• Family