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Article

Brain structure and function changes during the development of schizophrenia: the evidence from studies of subjects at increased genetic risk.

Schizophrenia bulletin - 1 Mar 2008

Lawrie Stephen M, McIntosh Andrew M, Hall Jeremy, Owens David G C, Johnstone Eve C

Abstract excerpt

This article reviews the evidence for changes in the structure and function of the brain in subjects at high risk of schizophrenia for genetic reasons during the genesis of the disorder. We first highlight the structural and functional abnormalities in schizophrenia and whether any similar or lesser abnormalities are apparent in unaffected relatives. There is good evidence for subtle abnormalities of hippocampal...

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Identifiers

PMID: 18227083
DOI: 10.1093/schbul/sbm158
PMCID: PMC2632417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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