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Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases.

Breast cancer research : BCR - 12 Jun 2012

Lotsari Johanna E, Gylling Annette, Abdel-Rahman Wael M, Nieminen Taina T, Aittomäki Kristiina, Friman Marjukka, Pitkänen Reino, Aarnio Markku, Järvinen Heikki J, Mecklin Jukka-Pekka, Kuopio Teijo, Peltomäki Päivi

Abstract excerpt

INTRODUCTION: Breast carcinoma is the most common cancer in women, but its incidence is not increased in Lynch syndrome (LS) and studies on DNA mismatch repair deficiency (MMR) in LS-associated breast cancers have arrived at conflicting results. This study aimed to settle the question as to whether breast carcinoma belongs to the LS tumor spectrum. METHODS: MMR status and epigenetic profiles were determined for...

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Identifiers

PMID: 22691310
DOI: 10.1186/bcr3205
PMCID: PMC3446353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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