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Article

Distinct molecular profiles in Lynch syndrome-associated and sporadic ovarian carcinomas.

International journal of cancer - 1 Dec 2013

Niskakoski Anni, Kaur Sippy, Renkonen-Sinisalo Laura, Lassus Heini, Järvinen Heikki J, Mecklin Jukka-Pekka, Bützow Ralf, Peltomäki Päivi

Abstract excerpt

Ovarian carcinoma in Lynch syndrome (LS) is associated with unexpectedly high survival; yet, beyond DNA mismatch repair (MMR) defects, the developmental mechanisms are unknown. We used established (genetic) and new (epigenetic) classifiers of ovarian cancer to explore similarities and differences between LS-associated and sporadic diseases. To this end, all available ovarian carcinomas (n = 20) from MMR gene...

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PMID: 23716351
DOI: 10.1002/ijc.28287

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BRAF
KRAS

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