Article
Spectrum of mismatch repair gene mutations and clinical presentation of Hispanic individuals with Lynch syndrome.
Cancer genetics - 1 Apr 2017
Sunga Annette Y, Ricker Charité, Espenschied Carin R, Castillo Danielle, Melas Marilena, Herzog Josef, Bannon Sarah, Cruz-Correa Marcia, Lynch Patrick, Solomon Ilana, Gruber Stephen B, Weitzel Jeffrey N
Abstract excerpt
Lynch syndrome (LS), the most common hereditary colorectal cancer syndrome, is caused by mismatch repair (MMR) gene mutations. However, data about MMR mutations in Hispanics are limited. This study aims to describe the spectrum of MMR mutations in Hispanics with LS and explore ancestral origins. This case series involved an IRB-approved retrospective chart review of self-identified Hispanic patients (n = 397)...
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