Article

Tumor analysis of MMR genes in Lynch-like syndrome: challenges associated to results interpretation

2023-08-09

Abstract excerpt

<title>Abstract</title> <p>Up to 70% of suspected Lynch syndrome patients harboring MMR deficient tumors lack identifiable germline pathogenic variants in MMR genes, being referred to as Lynch-like syndrome (LLS). Previous studies have reported biallelic somatic MMR inactivation in 15–95% LLS-associated tumors. However, translating tumor testing results into patient management remains controversial. Our aim is to...

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Literature Corpus work: e763b92b-381c-56a0-9d0f-313d59a9d4ea
DOI: 10.21203/rs.3.rs-3223657/v1

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