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Article

Dopamine transporter (DAT1) VNTR polymorphism and alcoholism in two culturally different populations of south India.

The American journal on addictions - 1 Jan 2000

Bhaskar Lakkakula V K S, Thangaraj Kumarasamy, Wasnik Samiksha, Singh Lalji, Raghavendra Rao Vadlamudi

Abstract excerpt

It is well established that the central dopaminergic reward pathway is likely involved in alcohol intake and the progression of alcohol dependence. Dopamine transporter (DAT1) mediates the active re-uptake of DA from the synapse and is a principal regulator of dopaminergic neurotransmission. The gene for the human DAT1 displays several polymorphisms, including a 40-bp variable number of tandem repeats (VNTR)...

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PMID: 22691013
DOI: 10.1111/j.1521-0391.2012.00244.x

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