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Article

Human dopamine transporter gene polymorphism (VNTR) and alcoholism.

American journal of medical genetics - 19 Sept 1997

Parsian A, Zhang Z H

Abstract excerpt

The dopamine transporter (DAT1) is responsible for taking released dopamine back up into presynaptic terminals and terminating dopaminergic activity. It has been shown that cocaine binds to the dopamine transporter and blocks dopamine reuptake in a fashion that correlates with cocaine reward and reinforcement. To determine the role of this gene in the development of alcoholism, we have used two approaches,...

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PMID: 9342195
DOI: 10.1002/(sici)1096-8628(19970919)74:5<480::aid-ajmg4>3.0.co;2-s

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