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Article

The pathophysiology of mitochondrial disease as modeled in the mouse.

Genes & development - 1 Aug 2009

Wallace Douglas C, Fan Weiwei

Abstract excerpt

It is now clear that mitochondrial defects are associated with a plethora of clinical phenotypes in man and mouse. This is the result of the mitochondria's central role in energy production, reactive oxygen species (ROS) biology, and apoptosis, and because the mitochondrial genome consists of roughly 1500 genes distributed across the maternal mitochondrial DNA (mtDNA) and the Mendelian nuclear DNA (nDNA). While...

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Identifiers

PMID: 19651984
DOI: 10.1101/gad.1784909
PMCID: PMC2720256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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