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Article

Investigating the relationship of DNA methylation with mutation rate and allele frequency in the human genome.

BMC genomics - 1 Jan 2012

Xia Junfeng, Han Leng, Zhao Zhongming

Abstract excerpt

BACKGROUND: DNA methylation, which mainly occurs at CpG dinucleotides, is a dynamic epigenetic regulation mechanism in most eukaryotic genomes. It is already known that methylated CpG dinucleotides can lead to a high rate of C to T mutation at these sites. However, less is known about whether and how the methylation level causes a different mutation rate, especially at the single-base resolution. RESULTS: In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23281708
DOI: 10.1186/1471-2164-13-S8-S7
PMCID: PMC3535710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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