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Article

Neural tube defects by NUAK1 and NUAK2 double mutation.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2012

Ohmura Tomomi, Shioi Go, Hirano Mariko, Aizawa Shinichi

Abstract excerpt

BACKGROUND: NUAK1 and NUAK2, members of the AMP-activated protein kinase family of serine/threonine kinases, are prominently expressed in neuroectoderm, but their functions in neurulation have not been elucidated. RESULTS: NUAK1 and NUAK2 double mutants exhibited exencephaly, facial clefting, and spina bifida. Median hinge point was formed, but dorsolateral hinge point formation was not apparent in cranial neural...

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Source

Identifiers

PMID: 22689267
DOI: 10.1002/dvdy.23816

Genes

NUAK1
NUAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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