Article
Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2010
Reid Bethany S, Sargent Thomas D, Williams Trevor
Abstract excerpt
Previous studies identified Inka1 as a gene regulated by AP-2alpha in the neural crest required for craniofacial morphogenesis in fish and frog. Here, we extend the analysis of Inka1 function and regulation to the mouse by generating a LacZ knock-in allele. Inka1-LacZ allele expression occurs in the cephalic mesenchyme, heart, and paraxial mesoderm prior to E8.5. Subsequently, expression is observed in the...
Topics
- Adaptor Proteins, Signal Transducing
- Alleles
- Amino Acid Sequence
- Animals
- Cloning, Molecular
- Female
- Gene Expression Regulation, Developmental
- Genetic Markers
- Lac Operon
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic