Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Do common variants separate between obese melanocortin-4 receptor gene mutation carriers and non-carriers? The impact of cryptic relatedness.

Hormone research in paediatrics - 1 Jan 2012

Mühlhaus Jessica, Pütter Carolin, Brumm Harald, Grallert Harald, Illig Thomas, Scherag Susann, Reinehr Thomas, Pott Wilfried, Albayrak Özgür, Wang Hai-Jun, Bau Anne-Madeleine, Wiegand Susanna, Grüters Annette, Krude Heiko, Hebebrand Johannes, Hinney Anke, Biebermann Heike, Scherag André

Abstract excerpt

BACKGROUND/AIMS: Genome-wide association studies revealed associations of single nucleotide polymorphisms (SNPs) flanking MC4R with body mass index variability and obesity. We genotyped 28 SNPs, covering MC4R, and searched for haplotypes discriminating between obese mutation carriers and non-carriers. METHODS: We analyzed all three-marker haplotype combinations of the 28 SNPs to discriminate between obese...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Mass Index
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Genome-Wide Association Study

Share to Heterozygote

Share to Obesity

Share to Receptor, Melanocortin, Type 4

Share to Young Adult

Source

Identifiers

PMID: 22688572
DOI: 10.1159/000338999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Do common variants separate between obese melanocortin-4 receptor gene mutation carriers and non-carriers? The impact of cryptic relatedness.PMID 22688572Read ↗

The role of polygenic susceptibility to obesity among carriers of pathogenic mutations in MC4R in the UK Biobank population.Semantic proximity Read ↗

The genetic epidemiology of melanocortin 4 receptor variants.Semantic proximity Read ↗

Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus.Semantic proximity Read ↗

Heterozygous versus homozygous phenotype caused by the same MC4R mutation: novel mutation affecting a large consanguineous kindred.Semantic proximity Read ↗

Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating.Semantic proximity Read ↗

The Clinical Phenotype and Genetic Analysis of Monogenic Non Syndromic Obesity Caused by MC4R Gene Variation.Semantic proximity Read ↗

Genetic Insights into Severe Obesity: A Case Study of MC4R Variant Identification and Clinical ImplicationsSemantic proximity Read ↗

Clinical and Biological Phenotypes of Patients Carrying a Heterozygous Variant in Genes of Leptin-Melanocortin Signaling Pathway.Semantic proximity Read ↗

Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis.Semantic proximity Read ↗

Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment.Semantic proximity Read ↗

Common variants near MC4R are associated with fat mass, weight and risk of obesity.Semantic proximity Read ↗

Descriptive analysis of MC4R gene variants associated with obesity listed on ClinVar.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.