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Article

The Clinical Phenotype and Genetic Analysis of Monogenic Non Syndromic Obesity Caused by MC4R Gene Variation.

Molecular genetics & genomic medicine - 1 Aug 2026

Li Xin, Wang Xiaotian, Liu Xin, Wang Shuping, Yang Wentao

Abstract excerpt

OBJECTIVE: The objective of this study was to investigate the clinical features and genetic variation of a patient with monogenic nonsyndromic obesity caused by melanocortin 4 receptor (MC4R) gene variation. Additionally, this study aims to provide a reference for the diagnosis of the disease. METHODS: A monogenic non syndromic obese patient who was admitted to Dongying People's Hospital in December 2024 was...

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Child
Exome Sequencing
Mutation
Mutation, Missense
Obesity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Melanocortin, Type 4

Regulation of Appetite and Obesity

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Open in PubMed Open full text

Identifiers

PMID: 42549640
DOI: 10.1002/mgg3.70276
PMCID: PMC13435259

Genes

MC4R

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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