Article
First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G.
Journal for immunotherapy of cancer - 1 Mar 2021
Anna François, Bole-Richard Elodie, LeMaoult Joel, Escande Marie, Lecomte Martin, Certoux Jean-Marie, Souque Philippe, Garnache Francine, Adotevi Olivier, Langlade-Demoyen Pierre, Loustau Maria, Caumartin Julien
Abstract excerpt
BACKGROUND: CAR-T cells immunotherapy is a breakthrough in the treatment of hematological malignancies such as acute lymphoblastic leukemia (ALL) and B-cell malignancies. However, CAR-T therapies face major hurdles such as the lack of tumor-specific antigen (TSA), and immunosuppressive tumor microenvironment sometimes caused by the tumorous expression of immune checkpoints (ICPs) such as HLA-G. Indeed, HLA-G is...
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