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Article

A Functional Role of HLA-G Expression in Human Gliomas: An Alternative Strategy of Immune Escape

1 May 2002

Abstract excerpt

HLA-G is a nonclassical MHC molecule with highly limited tissue distribution that has been attributed chiefly immune regulatory functions. Glioblastoma is paradigmatic for the capability of human cancers to paralyze the immune system. To delineate the potential role of HLA-G in glioblastoma immunobiology, expression patterns and functional relevance of this MHC class Ib molecule were investigated in glioma cells...

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PMID: 11971028
DOI: 10.4049/jimmunol.168.9.4772

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