Article
Aurora kinase B expression in breast carcinoma: cell kinetic and genetic aspects.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2012
Hegyi Katalin, Egervári Kristóf, Sándor Zsuzsa, Méhes Gábor
Abstract excerpt
BACKGROUND: Mitotic deregulations may contribute significantly to cell division errors and the development of aggressive tumor cells. The mitotic kinase Aurora B is essential for chromosome segregation. Its gene is located at 17p13 in close proximity to the TP53 gene. Although the frequent alteration of this locus is well known, the information about the AURKB status and protein expression is limited. METHODS: 50...
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