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Article

Elongation factor 1A is the target of growth inhibition in yeast caused by Legionella pneumophila glucosyltransferase Lgt1.

The Journal of biological chemistry - 27 Jul 2012

Belyi Yury, Tartakovskaya Dina, Tais Arlette, Fitzke Edith, Tzivelekidis Tina, Jank Thomas, Rospert Sabine, Aktories Klaus

Abstract excerpt

Legionella is a pathogenic Gram-negative bacterium that can multiply inside of eukaryotic cells. It translocates numerous bacterial effector proteins into target cells to transform host phagocytes into a niche for replication. One effector of Legionella pneumophila is the glucosyltransferase Lgt1, which modifies serine 53 in mammalian elongation factor 1A (eEF1A), resulting in inhibition of protein synthesis and...

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Source

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Identifiers

PMID: 22685293
DOI: 10.1074/jbc.M112.372672
PMCID: PMC3406686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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