Article
The Kluyveromyces lactis gamma-toxin targets tRNA anticodons.
RNA (New York, N.Y.) - 1 Nov 2005
Lu Jian, Huang Bo, Esberg Anders, Johansson Marcus J O, Byström Anders S
Abstract excerpt
Kluyveromyces lactis killer strains secrete a heterotrimeric toxin (zymocin), which causes an irreversible growth arrest of sensitive yeast cells. Despite many efforts, the target(s) of the cytotoxic gamma-subunit of zymocin has remained elusive. Here we show that three tRNA species tRNA(Glu)(mcm(5)s(2)UUC), tRNA(Lys)(mcm(5)s(2)UUU), and tRNA(Gln)(mcm(5)s(2)UUG) are the targets of gamma-toxin. The toxin inhibits...
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