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Article

Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase.

The Biochemical journal - 24 Feb 2010

Hurtado-Guerrero Ramon, Zusman Tal, Pathak Shalini, Ibrahim Adel F M, Shepherd Sharon, Prescott Alan, Segal Gil, van Aalten Daan M F

Abstract excerpt

Legionnaires' disease is caused by a lethal colonization of alveolar macrophages with the Gram-negative bacterium Legionella pneumophila. LpGT (L. pneumophila glucosyltransferase; also known as Lgt1) has recently been identified as a virulence factor, shutting down protein synthesis in the human cell by specific glucosylation of EF1A (elongation factor 1A), using an unknown mode of substrate recognition and a...

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Identifiers

PMID: 20030628
DOI: 10.1042/BJ20091351
PMCID: PMC3518269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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