Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Two Legionella pneumophila Effectors that Manipulate Host Phospholipids Biosynthesis

1 Nov 2012

Abstract excerpt

The intracellular pathogen Legionella pneumophila translocates a large number of effector proteins into host cells via the Icm/Dot type-IVB secretion system. Some of these effectors were shown to cause lethal effect on yeast growth. Here we characterized one such effector (LecE) and identified yeast suppressors that reduced its lethal effect. The LecE lethal effect was found to be suppressed by the over...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Legionella and Acanthamoeba research
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23133385
DOI: 10.1371/journal.ppat.1002988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Two Legionella pneumophila Effectors that Manipulate Host Phospholipids BiosynthesisPMID 23133385Read ↗

The Legionella pneumophila Dot/Icm-secreted effector PlcC/CegC1 together with PlcA and PlcB promotes virulence and belongs to a novel zinc metallophospholipase C family present in bacteria and fungi.Semantic proximity Read ↗

Legionella pneumophila Type IV Effectors YlfA and YlfB Are SNARE-Like Proteins that Form Homo- and Heteromeric Complexes and Enhance the Efficiency of Vacuole Remodeling.Semantic proximity Read ↗

Anchors for Effectors: Subversion of Phosphoinositide Lipids by LegionellaSemantic proximity Read ↗

Identification and Structural Characterization of a Legionella Phosphoinositide Phosphatase*Semantic proximity Read ↗

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.Semantic proximity Read ↗

<i>Legionella pneumophila</i> S1P-lyase targets host sphingolipid metabolism and restrains autophagySemantic proximity Read ↗

Characterization of the gene encoding the major secreted lysophospholipase A of Legionella pneumophila and its role in detoxification of lysophosphatidylcholine.Semantic proximity Read ↗

Multiple Legionella pneumophila effector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries.Semantic proximity Read ↗

Legionella effectors that promote nonlytic release from protozoa.Semantic proximity Read ↗

Intrabacterial regulation of a cytotoxic effector by its cognate metaeffector promotes <i>Legionella pneumophila</i> virulenceSemantic proximity Read ↗

Expression of Legionella pneumophila paralogous lipid A biosynthesis genes under different growth conditions.Semantic proximity Read ↗

Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.