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Article

Germline variants of base excision repair genes and breast cancer: A polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk.

International journal of cancer - 1 Jan 2013

Popanda Odilia, Seibold Petra, Nikolov Ivaylo, Oakes Christopher C, Burwinkel Barbara, Hausmann Sebastian, Flesch-Janys Dieter, Plass Christoph, Chang-Claude Jenny, Schmezer Peter

Abstract excerpt

Base excision repair (BER) removes DNA damage induced by endogenous reactive oxygen species or ionizing radiation, important breast cancer risk factors. Genetic variation associated with impaired BER might thus increase breast cancer risk. Therefore, we assessed risk associations of 123 common single nucleotide polymorphisms (SNPs) in 19 BER genes in 1,639 postmenopausal breast cancer cases and 1,967 controls...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22684821
DOI: 10.1002/ijc.27665

Genes

POLG
PARP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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