Article
Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis.
Journal of human genetics - 1 Sept 2009
Singh Keshav K, Ayyasamy Vanniarajan, Owens Kjerstin M, Koul Manika Sapru, Vujcic Marija
Abstract excerpt
Decreased mitochondrial oxidative phosphorylation (OXPHOS) is one of the hallmarks of cancer. To date, the identity of nuclear gene(s) responsible for decreased OXPHOS in tumors remains unknown. It is also unclear whether mutations in nuclear gene(s) responsible for decreased OXPHOS affect tumorigenesis. Polymerase-gamma (POLG) is the only DNA polymerase known to function in human mitochondria. Mutations in POLG...
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