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Article

A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.

BMC cancer - 19 Nov 2014

Brandalize Ana Paula Carneiro, Schüler-Faccini Lavínia, Hoffmann Jean-Sébastien, Caleffi Maira, Cazaux Christophe, Ashton-Prolla Patricia

Abstract excerpt

BACKGROUND: One of the hallmarks of cancer is the occurrence of high levels of chromosomal rearrangements as a result of inaccurate repair of double-strand breaks (DSB). Germline mutations in BRCA and RAD51 genes, involved in DSB repair, are strongly associated with hereditary breast cancer. Pol θ, a translesional DNA polymerase specialized in the replication of damaged DNA, has been also shown to contribute to...

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Identifiers

PMID: 25409685
DOI: 10.1186/1471-2407-14-850
PMCID: PMC4246548

Genes

POLQ
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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