Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status.

Journal of hematology & oncology - 8 Jun 2012

Faraoni Isabella, Laterza Serena, Ardiri Davide, Ciardi Claudia, Fazi Francesco, Lo-Coco Francesco

Abstract excerpt

BACKGROUND: MicroRNA have a central role in normal haematopoiesis and are deregulated in acute myeloid leukaemia (AML). The purpose of the study was to investigate by qRT-PCR the expression of miRNAs involved in myeloid differentiation (miR-424, miR-155, miR-223, miR-17-5p) in 48 patients with cytogenetically normal AML well characterized for NPM1 and/or FLT3 mutations. Three types of normalization were used for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to fms-Like Tyrosine Kinase 3
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Nuclear Proteins

Share to Nucleophosmin

Share to Oligonucleotide Array Sequence Analysis

Share to Real-Time Polymerase Chain Reaction

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 22681934
DOI: 10.1186/1756-8722-5-26
PMCID: PMC3416574

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status.PMID 22681934Read ↗

Differential expression of specific microRNA and their targets in acute myeloid leukemia.Semantic proximity Read ↗

Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients.Semantic proximity Read ↗

MicroRNA-155 expression and function in AML: An evolving paradigm.Semantic proximity Read ↗

Deregulation of miR-1, miR486, and let-7a in cytogenetically normal acute myeloid leukemia: association with NPM1 and FLT3 mutation and clinical characteristics.Semantic proximity Read ↗

MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemiaSemantic proximity Read ↗

Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia.Semantic proximity Read ↗

Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin.Semantic proximity Read ↗

Differentially expressed miRNAs in cytogenetic and molecular subtypes of pediatric acute myeloid leukemiaSemantic proximity Read ↗

miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death.Semantic proximity Read ↗

MicroRNA-155 as an inducer of apoptosis and cell differentiation in Acute Myeloid Leukaemia.Semantic proximity Read ↗

MicroRNAs in normal and malignant hematopoiesisSemantic proximity Read ↗

Downregulation of Mir-31, Mir-155, and Mir-564 in Chronic Myeloid Leukemia CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.