Article
Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia.
Haematologica - 1 Dec 2011
Russ Annika C, Sander Sandrine, Lück Sonja C, Lang Katharina M, Bauer Marion, Rücker Frank G, Kestler Hans A, Schlenk Richard F, Döhner Hartmut, Holzmann Karlheinz, Döhner Konstanze, Bullinger Lars
Abstract excerpt
BACKGROUND: MicroRNAs are regulators of gene expression, which act mainly by decreasing mRNA levels of their multiple targets. Deregulated microRNA expression has been shown for acute myeloid leukemia, a disease also characterized by altered gene expression associated with distinct genomic aberrations such as nucleophosmin (NPM1) mutations. To shed further light on the role of deregulated microRNA and gene...
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