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Article

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

The Journal of biological chemistry - 20 Jul 2012

Lohse Stefan, Brunke Christina, Derer Stefanie, Peipp Matthias, Boross Peter, Kellner Christian, Beyer Thomas, Dechant Michael, van der Winkel Jan G J, Leusen Jeanette H W, Valerius Thomas

Abstract excerpt

IgA antibodies constitute an important part of the mucosal immune system, but their immunotherapeutic potential remains rather unexplored, in part due to biotechnological issues. For example, the IgA2m(1) allotype carries an unusual heavy and light chain pairing, which may confer production and s...

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Topics

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Share to Antibodies, Neoplasm
Share to Antigens, CD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Cellular

Share to Immunoglobulin A

Share to Immunoglobulin Allotypes

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Share to Monocytes

Share to Receptors, Fc

Source

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Identifiers

PMID: 22679018
DOI: 10.1074/jbc.M112.353060
PMCID: PMC3408157

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22679018-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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