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Allosteric Effects between the Antibody Constant and Variable Regions: A Study of IgA Fc Mutations on Antigen Binding

2018-05-15

Abstract excerpt

Therapeutics antibodies have increasingly shifted the paradigm of disease treatments, from small molecules to biologics, especially in cancer therapy. Despite the increasing number of antibody candidates, much remains unknown about the antibody and how its various regions interact. In fact, the constant region can govern effects that might be useful in reducing the unwanted consequences resulted from systemic circ...

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Literature Corpus work
afae8edc-a49c-52c1-8a1b-7976a09dd8e0
DOI
10.20944/preprints201805.0207.v1
Open publication

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Allosteric Effects between the Antibody Constant and Variable Regions: A Study of IgA Fc Mutations on Antigen BindingDOI 10.20944/preprints201805.0207.v1
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