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Antibody Fc-chimerism and effector functions: When IgG takes advantage of IgA

2 Feb 2023

Abstract excerpt

Recent advances in the development of therapeutic antibodies (Abs) have greatly improved the treatment of otherwise drug-resistant cancers and autoimmune diseases. Antibody activities are mediated by both their Fab and the Fc. However, therapeutic Abs base their protective mechanisms on Fc-mediated effector functions resulting in the activation of innate immune cells by FcRs. Therefore, Fc-bioengineering has been...

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Identifiers

PMID: 36817447
DOI: 10.3389/fimmu.2023.1037033

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