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Antibody Isotypes for Tumor Immunotherapy

1 Jan 2017

Abstract excerpt

Compared to the evolutionary diversity of antibody isotypes, the spectrum of currently approved therapeutic antibodies is biased to the human IgG1 isotype. Detailed studies into the different structures and functions of human isotypes have suggested that other isotypes than IgG1 may be advantageous for specific indications - depending on the complex interplay between the targeted antigen or epitope, the desired...

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PMID: 29070977
DOI: 10.1159/000479240

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