Article
ENU induced mutations causing congenital cardiovascular anomalies.
Development (Cambridge, England) - 1 Dec 2004
Yu Qing, Shen Yuan, Chatterjee Bishwanath, Siegfried Brett H, Leatherbury Linda, Rosenthal Julie, Lucas John F, Wessels Andy, Spurney Chris F, Wu Ying-Jie, Kirby Margaret L, Svenson Karen, Lo Cecilia W
Abstract excerpt
We used non-invasive high frequency ultrasound to screen N-ethyl-N-nitrosourea mutagenized mouse fetuses for congenital cardiovascular anomalies. We ultrasound scanned 7546 mouse fetuses from 262 mutagenized families, and identified 124 families with cardiovascular defects. Represented were most of the major congenital cardiovascular anomalies seen clinically. The ENU-induced mutations in several families were...
Topics
- Amino Acid Sequence
- Animals
- Chromosomes, Mammalian
- Connexin 43
- DiGeorge Syndrome
- Ethylnitrosourea
- Female
- Fetus
- Heart Defects, Congenital
- Limb Deformities, Congenital
- Mice
- Molecular Sequence Data
- Mutation