Article

DDX41 is needed for pre-and post-natal hematopoietic stem cell differentiation in mice

2021-08-13

Abstract excerpt

DDX41 is a tumor suppressor frequently mutated in human myeloid neoplasms. DDX41 binds to DNA/RNA hybrids and interacts with spliceosome component (1, 2). How it affects hematopoiesis is still unclear. Using a knockout mouse model, we demonstrate that DDX41 is required for mouse hematopoietic stem and progenitor cell (HSPC) survival and differentiation. Lack of DDX41 particularly affected myeloid progenitor develo...

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Literature Corpus work: 078a6bc0-9590-5e6e-89c8-35485cec7c0a
DOI: 10.1101/2021.08.13.456151

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